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Content tagged with: Toxicology
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Alternative Test Strategies, Predictive Models to Assist Nanomaterials Safety Assessment

Aug. 2013- With the exponential growth of engineered nanomaterials (ENMs) extending from research and development to commercial products, the daunting challenge of conducting effective risk assessment and life-cycle analysis for these materials is presented. Of primary concern is the potential for human exposure that may lead to adverse outcomes, which traditionally utilizes animal studies and specific ...

NanoBusiness Interview: Andrew Maynard, Ph.D.

Feb. 2012- I have known Andrew Maynard for over 10 years. We have agreed and disagreed on various EHS issues concerning the Nanotechnology Community during our relationship. Even though we have disagreed from time to time I have always found his opinions valuable and thought provoking.Andrew previously co-chaired the NNI’s Nanotechnology Health and Environment Implications group while working at the ...

NanoBusiness Provides Insight on National Research Council Report

Feb. 2012- The National Research Council (NRC) of the National Academies has been working for several years on the development of a Research Strategy for Environmental, Health, and Safety Aspects of Engineered Nanomaterials. On January 25th they released a draft of this strategy, which is available from the National Academies website. This work was commissioned by the Environmental Protection Agency. A ...

Responsible Development of Nanotechnology: Maximizing Results while Minimizing Risk

Oct. 2011- Nanotechnology holds the promise of new materials and devices that can be designed and engineered to solve critical questions in almost every sector of our economy – from treating cancer, to cleaning contaminated water, accelerating advanced manufacturing, meeting energy needs, and fixing our roadways and bridges. That’s why, for the last 10 years, the United States has engaged in an ...

ONAMI Fellow Studies Safety, Toxicology of Nanoparticles

Dec. 2009- Stacey Harper, a nationally recognized leader in the interactions of nanomaterials with biological systems, has been named as the sixth “signature research faculty fellow” of the Oregon Nanoscience and Microtechnologies Institute, or ONAMI.

NIEHS Call for Applications to Study Engineered Nanomaterials Interactions with Biological Processes

Nov. 2009- The National Institute of Environmental Health Sciences (NIEHS) announced a new funding opportunity to understand how physical and chemical characteristics of engineered nanomaterials (ENMs) influence their molecular  interactions with biological matrices and elicit biological responses. Letters of intent are due by December 22, 2009. 

NNI nanoEHS Workshop Brief: Nanomaterials and Human Health & Instrumentation, Metrology, and Analytical Methods, November 17-18, 2009

Nov. 2009- On November 17 and 18 the National Nanotechnology Initiative (NNI) held the third of four workshops in its nanoEHS series. The series is an effort to review the state of research in what is now the NNI’s fastest growing program component area: Environmental, Health, and Safety Research.

Hazardous Substances Data Bank Adds First Set of Nanomaterials Records

Nov. 2009- In October, the National Library of Medicine's Hazardous Substances Data Bank (HSBD)—a comprehensive, peer-reviewed database of toxicology information for over 5,000 chemicals—added seven nanomaterials records, the first set of such records in the datafile.

Study of Chinese Print Workers Claims to Provide the First Human Evidence of the Clinical Toxicity of Long-term Nanoparticle Exposures

Oct. 2009- A recent study published in the well-known medical journal, the European Respiratory Journal, has been receiving significant publicity as the authors have claimed their findings support an apparent linkage between workplace exposures to nanoparticles and severe respiratory disease.  Specifically, in this study, investigators at China's Capital University of Medical Science related ...

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Carbon Nanotubes Introduced into the Abdominal Cavity of Mice Show Asbestos-like Pathogenicity in a Pilot Study

Carbon nanotubes have distinctive characteristics, but their needle-like fibre shape has been compared to asbestos, raising concerns that widespread use of carbon nanotubes may lead to mesothelioma, cancer of the lining of the lungs caused by exposure to asbestos. Here we show that exposing the mesothelial lining of the body cavity of mice, as a surrogate for the mesothelial lining of the chest ...

Considerations on Occupational Medical Surveillance in Employees Handling Nanoparticles

The use of engineered nanoparticles not only offers new technical perspectives but also raises questions regarding possible health aspects for producers and users. Nanoparticles may, just by virtue of their size, exert biological effects unrelated to the chemicals they are composed of. These considerations, and results from experimental animal studies suggesting that engineered nanomaterials may ...

Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells

Silver nanoparticles (Ag-np) are being used increasingly in wound dressings, catheters, and various household products due to their antimicrobial activity. The toxicity of starch-coated silver nanoparticles was studied using normal human lung fibroblast cells (IMR-90) and human glioblastoma cells (U251). The toxicity was evaluated using changes in cell morphology, cell viability, metabolic ...

EPA Perspectives on Nanoinformatics: Prioritization Based on Potential for Exposure and ToxicityNanoinformatics

The U.S. Environmental Protection Agencys (EPA) Office of Research and Development (ORD) is investigating the environmental health and safety implications of engineered nanomaterials. Research activities as outlined in ORDs Nanomaterial Strategy address four main themes in: 1) identifying sources, fate, transport, and exposure; 2) understanding human health and ecological effects; 3) developing ...

EPA Whitepaper on Nanotechnology

The EPA Nanotechnology White Paperwas issued in February 2007 by the EPA's Science Policy Council and includes discussion of risk assessment, responsible development, and research needs for environmental applications.

EPA and Nanotechnology: Oversight for the 21st Century

This paper focuses on the need for an oversight system for nanotechnology that will identify any potential adverse health or environmental effects of the technology and prevent them from occurring. It analyzes the steps that must be taken to create such a system, particularly emphasizing the role of the U.S. Environmental Protection Agency (EPA).

Effect of pharmaceuticals on thermoreversible gelation of PEOPPOPEO copolymers

Pluronic F127, a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), has generated considerable interest as a drug delivery vehicle due to its ability to gel at physiological temperatures. This work examines the gelation behavior of Pluronic F127 in the presence of a series of hydrophobic pharmaceuticals, to determine whether there is any correlation between gelation ...

Engineered Nanomaterials: Linking Physiochemical Properties with Biology

Serious concerns over potential toxicity of new engineered nanomaterials (ENMs) require the development of reliable and high throughput screening assays that impart critical information regarding potential toxicity, guide in-depth toxicity evaluations, justify exposure controls, and aid in the development of sustainable nanomanufacturing. Reactive oxygen species (ROS) generation or biological ...

Exposure to diesel exhaust induces changes in EEG in human volunteers

Background: Ambient particulate matter and nanoparticles have been shown to translocate to the brain, and potentially influence the central nervous system. No data are available whether this may lead to functional changes in the brain. Methods: We exposed 10 human volunteers to dilute diesel exhaust (DE, 300 ?g/m3) as a model for ambient PM exposure and filtered air for one hour using a double ...

Induction of mesothelioma in p53+/? mouse by intraperitoneal application of multi-wall carbon nanotube

Nanomaterials of carbon origin tend to form various shapes of particles in micrometer dimensions. Among them, multi-wall carbon nanotubes (MWCNT) form fibrous or rod-shaped particles of length around 10 to 20 micrometers with an aspect ratio of more than three. Fibrous particles of this dimension including asbestos and some man-made fibers are reported to be carcinogenic, typically inducing ...

Nanoinformatics 2011 Supports Updated NNI EHS Research Strategy

The responsible development of nanotechnology has an impact across essentially all economic sectors, including advanced manufacturing. As core research areas of the recently released 2011 National Nanotechnology Initiative (NNI) Environmental Health and Safety (EHS) Research Strategy include a nanomaterials measurement infrastructure, as well as informatics and modeling, it has become evident ...

Nanomaterials properties vs. biological oxidative damage: Implications for toxicity screening and exposure assessment

Biological oxidative damage (BOD) has been recognized as a key toxicity mechanism with potential as a novel global metric for nanomaterial (NM) exposure and rapid toxicity screening. A 'Ferric reducing ability of serum (FRAS)' assay, recently optimized by our group, was used to quantitate the degree of BOD induced by 19 diverse, commercially important NMs, including carbon blacks, fullerenes, ...

Nanotechnology Changing the Status Quo in the Health Care Industry

Nanotechnologies have the potential to create a paradigm shift in the doctor-patient relationship and ultimately change the status quo for health care as we know it. Also: Nanoparticle-Polymer Array-Based Sensors for Biomedical Applications; Hazardous Substances Data Bank Adds First Set of Nanomaterial Records; Study of Chinese Print Workers Claims Evidence of Nanoparticle Toxicity.

Nanotoxicology as a Predictive Science That Can Be Explored by High Content Screening and the Use of Computer-assisted Hazard Ranking

I will discuss the use of high throughput screening for in vitro toxicological assessment and hazard ranking that can be used for planning and following in vivo outcomes. I will demonstrate the use of engineered nanomaterial libraries and the use of an oxidative stress paradigm to establish a multi-parametric, rapid throughput screening procedure that can be used to screen for potentially ...

Strategy for Nanotechnology-Related EHS Research

This report describes the NNI strategy for prioritizing research on the environmental health and safety aspects of nanomaterials that have been identified in previous NNI reports.

Why a Prevention-Based Approach to Managing the Risks of Engineered Nanomaterials Makes Sense and How To Get There

The existing toxicology literature on ultrafine particles and engineered nanomaterials suggest that nanomaterials may pose a threat to human health and the environment. A major challenge for the companies that produce and use these materials and for regulatory agencies is the issue of how to manage the risks of these materials while simultaneously leveraging the technological advantages that ...

Organizations

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Ablynx

Ablynx

Ablynx is focused on the discovery and development of Nanobodies®, a novel class of antibody-derived therapeutic proteins based on single-domain antibody fragments, for a range of serious life-threatening human diseases. Ablynx is developing a portfolio of Nanobody®-based therapeutic programmes in a number of major disease areas, including inflammation, thrombosis, oncology and Alzheimer's ...

Abraxis Oncology

Abraxis Oncology

Abraxis Oncology® is the proprietary pharmaceuticals division of Abraxis BioScience, LLC, an integrated global bio-pharmaceutical company. Abraxis Oncology® is dedicated to the discovery and development of novel cancer therapies that target tumor biological pathways. Our focus is to challenge current standards and develop next-generation therapies that revolutionize the treatment of cancer.

Accelrys, Inc.

Accelrys, Inc.

Accelrys (NASDAQ:ACCL), a leading scientific enterprise R&D software and services company, supports industries and organizations that rely on scientific innovation to differentiate themselves. Accelrys’ Enterprise R&D Architecture, built on the industry leading Pipeline Pilot™ platform, enables customers to access, organize, analyze and share scientific data in unprecedented ways, ultimately ...

Acron Genomics

Acron Genomics

We were the first to identify the combination of microfluidics and light responsive polymers being developed by Molecular Vision in London as having the potential of completely revolutionising the Point of Care (PoC) diagnostics market. This lab on a chip diagnostic platform has the potential to produce simple to use compact, low cost, hand held device where the analytical capabilities of a ...

AcryMed

AcryMed

AcryMed is a pioneering innovator at the forefront of discoveries in the fields of infection control and wound healing. The company’s SilvaSorb® products for advanced wound care and SilvaGard® antimicrobial surface treatment for medical devices are among the breakthrough technologies that have distinguished AcryMed as an industry leader. AcryMed's latest product line is OxygeneSys™ ...

Active Surface Technologies, Inc.

Active Surface Technologies, Inc.

Active Surface Technologies, Inc is a private company categorized under Laboratories-Research and Development and located in Boylston, MA. It was established in 2005 and incorporated in Massachusetts.

Agilent Technologies

Agilent Technologies

Agilent Life Sciences and Chemical Analysis is a leading global provider of instrumentation, supplies, software and services to the life science and chemical analysis markets. Agilent provides the worlds most complete, most reliable laboratory productivity solutions, optimized for your applications and workflows. Agilent's complete menu of services includes instrument maintenance and ...

Alkermes Inc

Alkermes Inc

Alkermes focuses on therapies for widespread, chronic diseases, such as central nervous system disorders, addiction, diabetes and autoimmune disorders, where we feel we have the opportunity to make the greatest impact.

BioTrove Inc.

BioTrove Inc.

BioTrove, Inc. provides micro and nano-scale technology platforms for life science and drug discovery research applications. The company offers OpenArray, a technology platform for relative gene expression analysis that advances genomic research in various life science fields, including agriculture, disease research, and public health; RapidFire, a technology platform that enables the ...

Caliper Life Sciences, Inc.

Caliper Life Sciences, Inc.

Caliper Life Sciences is a leading provider of cutting-edge technologies enabling researchers in the life sciences to create life-saving and enhancing medicines and diagnostic tests more quickly and efficiently. Caliper has compiled numerous best-in-class solutions and is aggressively innovating new technologies to bridge the gaps that exist in bringing in vitro assays to in vivo results ...

Center for Risk Science Innovation and Application

Center for Risk Science Innovation and Application

International Life Sciences Institute
The ILSI Center for Risk Science Innovation and Application (RSIA) contributes to enhanced human health and well-being by developing new and improving existing methods and evaluations used in risk management. RSIA is currently engaged in projects on timely issues such as nanomaterial release and characterization, dose-response relationships, and ...

ENVIRON International Corporation, Inc.

ENVIRON International Corporation, Inc.

An international environmental and health sciences consultancy, ENVIRON works with clients to assess and manage the potential environmental, energy, and health issues associated with their activities and products, including nanotechnology, throughout the business life cycles. ENVIRON's efforts in nanotechnology are focused on working with companies, law firms and organizations to develop a ...

eSpin Technologies, Inc.

eSpin Technologies, Inc.

eSpin Technologies, Inc. is a high-tech manufacturing company. The company provides global leadership in polymeric nanofiber manufacturing technology applicable across the universe of emergent and traditional manufacturing sectors. eSpin's nanofibers are 20-200nm in diameter, have a very high surface area to mass ratio, and can be formed into membranes with very high porosity. As a ...

FEI Company

FEI Company

FEI is a leading diversified scientific instruments company. It is a premier provider of electron and ion-beam microscopes and tools for nanoscale applications across many industries: industrial and academic materials research, life sciences, semiconductors, data storage, natural resources and more. FEI's imaging systems provide 3D characterization, analysis and modification/prototyping with ...

Icet Inc.

Icet Inc.

ICET (Innovative Chemical and Environmental) is a research and technology development company founded with the goal of developing technologies that benefit the environment and humanity. ICET is developing technologies in the areas of energy, environment, and biomedicine. ICET's major strength is in chemistry, organic-inorganic hybrid compositions, controlled delivery of actives from novel ...

JEOL USA

JEOL USA

JEOL develops instruments used to advance scientific research and technology. JEOL has expertise in the field of electron microscopy, mass spectrometry and NMR spectrometry, and e-beam lithography leadership.

Liquidia Technologies

Liquidia Technologies

Liquidia Technologies is developing engineered particle-based vaccines and therapeutics that have the potential to dramatically improve the quality of human life. Utilizing a novel technology known as the PRINT® platform, Liquidia is creating rationally-design carriers for improved delivery of small molecule and biological cargos. By designing highly specific particles that deliver ...

Mechartes Researchers Pvt. Ltd.

Mechartes Researchers Pvt. Ltd.

CFD Simulations
Simulation services company, providing advanced CFD services using OpenFOAM solver. Incubated at Indian Institute of Technology (Delhi) by alumni and professors of IIT Delhi.

nanoTox, Inc.

nanoTox, Inc.

nanoTox, Inc. is the premier nanotechnology safety, risk assessment and toxicology company helping companies commercialize their nanotechnology and nano-enabled products. The dedicated scientists and professional at nanoTox, Inc. understand that nanotechnology will reach its full potential only when issues of health and environmental safety are fully resolved. There are over 1,000 ...

Oregon Nanoscience and Microtechnologies Institute

Oregon Nanoscience and Microtechnologies Institute

Oregon Signature Research Center
ONAMI is Oregon’s first ‘Signature Research Center’ and a multi-level collaboration among Oregon’s research universities, Pacific Northwest National Laboratory and industry in the “Silicon Forest” high-tech cluster that is home to the world’s leading semiconductor, MEMS, nanotechnology tools and ...

SAFENANO

SAFENANO

Institute of Occupational Medicine
SAFENANO exists to help industrial and academic communities identify, assess and control the risks to their workforce, consumers, the general population and the environment, through both information provision and scientific services.

Individuals

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Stacey Harper

Stacey Harper

Environmental and Molecular Toxicology
Oregon State University

Angela R. Hight Walker

Angela R. Hight Walker

National Institute of Standards and Technology (NIST)

Alex G. Fassbender

Alex G. Fassbender

Lockheed Martin Corporation

Don Ewert

Don Ewert

nanoTox, Inc.

Jo Anne Shatkin

Jo Anne Shatkin

Vireo Advisors, LLC